Signs and Symptoms
There can be a large variation in the signs and symptoms of PNH both between patients and in the same patient at different times.
Some people exhibit no symptoms and others may be affected by a number of very different ones as well as complications.
Patients with no or few symptoms can still suffer from complications. Over time, the symptoms experienced by a PNH patient can change. Some patients only experience symptoms when an episode of severe haemolysis is occurring (which is usually triggered by an infection) and others may experience symptoms all the time. A list of possible symptoms include: abdominal and back pain, anaemia, blood clots, breathlessness, bruising, dysphagia (difficulty swallowing), erectile dysfunction, fatigue, jaundice, kidney damage and haemoglobinuria (dark or red urine caused by free haemoglobin as a result of destruction of red blood cells).